| Number of published RCTs |
180 |
12 |
82 |
86 |
| Number of published RCTs with major discrepancies between registry and publication |
87 |
(48%) |
9 |
(75%) |
29 |
(35%) |
52 |
(60%) |
| Number of major discrepancies between registry and publication |
180 |
19 |
55 |
106 |
| Registered primary outcomes demoted in publication |
10 |
(6%) |
4 |
(21%) |
2 |
(4%) |
4 |
(4%) |
| Registered primary outcomes omitted from publication |
38 |
(21%) |
5 |
(26%) |
16 |
(29%) |
17 |
(16%) |
| Unregistered primary outcomes added to publication |
61 |
(34%) |
2 |
(11%) |
18 |
(33%) |
41 |
(39%) |
| Registered secondary outcomes promoted in publication |
18 |
(10%) |
1 |
(5%) |
4 |
(7%) |
13 |
(12%) |
| Timing of assessment of primary outcomes differs |
53 |
(29%) |
7 |
(37%) |
15 |
(27%) |
31 |
(29%) |
| Number of major discrepancies between registry and publication |
180 |
19 |
55 |
106 |
| Did not report p-values |
7 |
(4%) |
2 |
(11%) |
3 |
(5%) |
2 |
(2%) |
| Reported p-values |
82 |
(46%) |
5 |
(26%) |
21 |
(38%) |
56 |
(53%) |
| Major discrepancy favors statistical significance |
52 |
(63%) |
3 |
(60%) |
14 |
(67%) |
38 |
(68%) |
| Major discrepancy does not favor statistical significance |
33 |
(40%) |
2 |
(40%) |
7 |
(33%) |
18 |
(32%) |
| Number of RCTs containing major discrepancies favoring statistical significance |
38 |
3 |
10 |
25 |
