Table 4. Year-by-year frequency of major discrepancies between published and registered outcomes in RCTs registered before or during patient enrollment (n = 181), and the effect of these discrepancies on the statistical significance of published outcomes, by year.
Publication year | No. of major discrepancies | No. of evaluable discrepancies, | No. of evaluable discrepancies whose discrepancies favor statistically significant results | ||
---|---|---|---|---|---|
2011 | 25 | 14 | 56% | 7 | 50% |
2012 | 42 | 19 | 45% | 16 | 84% |
2013 | 20 | 10 | 50% | 3 | 30% |
2014 | 62 | 25 | 40% | 19 | 76% |
2015 | 27 | 13 | 48% | 7 | 54% |
2016 | 4 | 2 | 50% | 0 | 0% |
Total | 180 | 82 | 46% | 52 | 63% |