Skip to main content
. 2017 Jul 20;12(7):e0181178. doi: 10.1371/journal.pone.0181178

Fig 1. Chemical structures of the tyrosine kinase inhibitors used in this study.

Fig 1

Compounds include the diaminopyrimidine TAE-684, the pyrrolopyridine HG7-92-01, and the pyrazolo-pyrimidine, WZ4-49-1. The discovery and characterization of these compounds as cell-active inhibitors of Fes kinase activity is described in Hellwig, et al. [16]. Tandutinib (CT-53518; MLN-518) is a piperazinyl quinazoline inhibitor of Flt3-ITD, c-Kit and the PDGF-R [18,19] that does not inhibit Fes in vitro or in cells (this study).