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. Author manuscript; available in PMC: 2017 Jul 20.
Published in final edited form as: Exp Hematol. 2008 Aug 23;36(11):1471–1479. doi: 10.1016/j.exphem.2008.06.006

Figure 3. UPD of 1p and point mutations of MPL in PMF.

Figure 3

A: Two cases of PMF with clear UPD in 1p region are shown. Green bars indicate heterozygous SNPs. Regions with pink lines show those regions with loss of heterozygosity but with normal DNA copy number (uniparental disomy). Position of MPL gene is indicated by an arrow. Point mutations of MPL found in 2 PMF cases are shown: S204F (B) and W515L (C). The sequences were determined by direct sequencing. Sequences of normal alleles are shown in upper panels.