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. Author manuscript; available in PMC: 2017 Jul 20.
Published in final edited form as: Exp Hematol. 2008 Aug 23;36(11):1471–1479. doi: 10.1016/j.exphem.2008.06.006

Figure 4. Non-dominant clones with 1p UPD in MPD were detected by SNP-chip.

Figure 4

Top panels: Allele-specific gene dosage analysis. Blue lines above the chromosomal panels indicate levels of total gene dosage (0 indicates 2N, normal diploid). Green and red lines below the chromosomal panels indicate respective parental allele gene dosage. Higher level of the red line and lower level of the green line indicates the regions of UPD. Middle and bottom panels: normal (middle) and mutated (bottom) nucleotide sequences of the MPL gene encoding amino-acid positions at 515 and 591; PMF case 325 (A) had W515L mutation and PV case 298 (B) had Y591D mutation.