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. Author manuscript; available in PMC: 2018 Jul 5.
Published in final edited form as: Neuron. 2017 Jul 5;95(1):19–32. doi: 10.1016/j.neuron.2017.05.021

Figure 3.

Figure 3

Plasticity of pauses in spike firing is mediated by an intrinsic mechanism. (A) Typical trace from an in vitro Purkinje cell recording showing simple spike firing evoked by depolarizing current injection and a complex spike triggered by climbing fiber stimulation. The complex spike pause is measured as the interval between the complex spike onset and the next subsequent simple spike (gray area). (B) Top: typical traces (green) show that 5 Hz injection of depolarizing currents causes a shortening of the spike pause. In contrast, pause duration remains stable in control recordings (black traces). Bottom: time graph showing that the intrinsic plasticity protocol shortens the pause duration, while the pause remains unaltered in non-tetanized cells. (C) In SK2−/− Purkinje cells, no pause plasticity is observed. (D) Golgi staining of Purkinje cells in WT (top) and SK2−/− mice (bottom). Scale bar: 50µm. This figure is reproduced from Grasselli et al. (2016). Copyright 2016 by Elsevier.