Table 2. Areas under the receiver operating characteristic curve (AROC) of the diagnostic tools.
| Exam | AROC | (95% CI) | P* | P † | |
|---|---|---|---|---|---|
| DDLS | 0.92 | (0.87–0.97) | <0.001 | N.A. | |
| Disc stereophotograph | |||||
| Vertical C/D ratio | 0.94 | (0.89–0.98) | <0.001 | 0.51 | |
| Horizontal C/D ratio | 0.91 | (0.85–0.96) | <0.001 | 0.66 | |
| HRT II | |||||
| C/D area ratio (global) | 0.81 | (0.72–0.90) | <0.001 | 0.006 | |
| Vertical C/D ratio | 0.83 | (0.74–0.91) | <0.001 | 0.01 | |
| Horizontal C/D ratio | 0.79 | (0.69–0.89) | <0.001 | 0.006 | |
| Cup shape measure | 0.77 | (0.66–0.87) | <0.001 | 0.002 | |
| Rim Area | |||||
| Global | 0.70 | (0.58–0.82) | 0.002 | <0.001 | |
| Temporal | 0.66 | (0.54–0.79) | 0.01 | <0.001 | |
| Superior Temporal | 0.75 | (0.64–0.86) | <0.001 | <0.001 | |
| Inferior Temporal | 0.70 | (0.58–0.82) | 0.002 | <0.001 | |
| Nasal | 0.62 | (0.50–0.74) | 0.07 | <0.001 | |
| Superior Nasal | 0.70 | (0.57–0.82) | 0.002 | <0.001 | |
| Inferior Nasal | 0.63 | (0.50–0.75) | 0.05 | <0.001 | |
| Stratus OCT | |||||
| Optic disc | |||||
| Rim area | 0.82 | (0.73–0.91) | <0.001 | 0.03 | |
| C/D area ratio | 0.89 | (0.82–0.96) | <0.001 | 0.44 | |
| Vertical C/D ratio | 0.89 | (0.82–0.96) | <0.001 | 0.46 | |
| Horizontal C/D ratio | 0.86 | (0.79–0.94) | <0.001 | 0.19 | |
| RNFL thickness | |||||
| Average | 0.79 | (0.69–0.89) | <0.001 | 0.01 | |
| Inferior | 0.77 | (0.67–0.87) | <0.001 | 0.007 | |
| Nasal | 0.73 | (0.62–0.84) | <0.001 | 0.004 | |
| Superior | 0.71 | (0.60–0.83) | 0.001 | 0.001 | |
| Temporal | 0.61 | (0.50–0.73) | 0.07 | <0.001 | |
| Spectralis OCT | |||||
| RNFL thickness | |||||
| Global | 0.83 | (0.75–0.91) | <0.001 | 0.04 | |
| Inferior | 0.81 | (0.72–0.90) | <0.001 | 0.01 | |
| Nasal | 0.75 | (0.65–0.85) | <0.001 | 0.003 | |
| Superior | 0.80 | (0.71–0.89) | <0.001 | 0.01 | |
| Temporal | 0.69 | (0.59–0.80) | 0.001 | <0.001 | |
| GDx-VCC | |||||
| NFI | 0.81 | (0.72–0.91) | <0.001 | 0.06 | |
| TSNIT Average | 0.78 | (0.68–0.89) | <0.001 | 0.02 | |
| Superior Average | 0.77 | (0.66–0.88) | <0.001 | 0.01 | |
| Inferior Average | 0.76 | (0.65–0.87) | <0.001 | 0.007 | |
| Visual field mean deviation index | 0.74 | (0.62–0.85) | <0.001 | 0.001 | |
Abbreviations: CI, confidence interval; DDLS, Disc Damage Likelihood Scale; N.A., not applicable; C/D, cup-to-disc; HRT, Heidelberg retina tomograph
OCT, optical coherence tomography; RNFL, retinal nerve fiber layer; GDx-VCC, scanning laser polarimetry with variable corneal compensation; NFI, nerve fiber indicator; TSNIT, temporal-superior-nasal-inferior-temporal.
* Comparison with AROC of 0.05
† Comparison with AROC for DDLS.