Table 2. Main characteristics of studies involved in this meta-analysis of the PPARG C161T polymorphism and essential hypertension risk.
| First author | Year | Country | Ethnicity | Source of control | Mean age (y) (case/control) | Sample size (case/control) | Cases | Controls | Genotyping methods | MAF (%) | HWE (Y/N) | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CC | CT | TT | CC | CT | TT | ||||||||||
| Qu FZ | 2005 | China | Asian | HB | 49.0±10.0/ 46.0±12.0 | 160/ 116 | 121 | 34 | 5 | 70 | 42 | 4 | PCR-RFLP | 21.55 | Y |
| Lin Y | 2012 | China | Asian | PB | 52.1±9.9/ 49.0±9.0 | 269/ 551 | 140 | 108 | 21 | 278 | 218 | 55 | TaqMan | 29.76 | Y |
| Chen J | 2014 | China | Asian | PB | 45.1±12.9/ 42.4±11.6 | 144/ 165 | 90 | 49 | 5 | 96 | 64 | 5 | MALDI-TOF-MS | 22.42 | Y |
| Zhang Y | 2014 | China | Asian | HB | 63.9±10.8/ 63.3±9.5 | 393/ 405 | 270 | 108 | 15 | 204 | 177 | 24 | PCR-RFLP | 27.78 | Y |
| Grygiel-Górniak B | 2015 | Poland | Caucasian | HB | 59.9±5.1/ 58.6±5.9 | 151/ 120 | 107 | 39 | 5 | 91 | 27 | 2 | PCR-RFLP | 12.92 | Y |
MAF, minor allelic frequency; HWE, Hardy-Weinberg equilibrium; PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism;HB, hospital based; PH, population based; Y, yes; N, no.