Table 3. Mediation analysis investigating the association between SSB intake and T2DM incidence in 2013 mediated by various measures of adiposity in 2009 in female TCS participants.
| Mediator in 2009 | Natural direct effect OR (95% CI) | Natural indirect effect OR (95% CI) | Total effect OR (95% CI) | Proportion mediated % |
|---|---|---|---|---|
| Body mass index (BMI/m2) | ||||
| BMI–overweight (23 kg m−2) | 1.74 (0.93–3.26) | 1.04 (0.95–1.15) | 1.81 (0.96–3.42) | 6.6 |
| BMI–obese I (25 kg m−2) | 1.58 (0.83–2.98) | 1.15 (1.02–1.31) | 1.82 (0.95–3.47) | 23.3 |
| BMI–obese II (30 kg m−2) | 1.50 (0.77–2.93) | 1.29 (1.04–1.61) | 1.94 (0.98–3.84) | 38.4 |
| Weight gain (2005-2009) | ||||
| Gained 5 kg or more | 1.95 (1.05–3.61) | 1.02 (0.97–1.08) | 1.99 (1.07–3.69) | 2.9 |
| Gained 10 kg or more | 1.91 (1.03–3.56) | 1.03 (0.96–1.11) | 1.98 (1.06–3.67) | 4.3 |
| Waist Circumference | ||||
| 80 centimetres or over | 1.62 (0.82–3.21) | 1.07 (0.98–1.18) | 1.74 (0.88–3.46) | 12.2 |
| 85 centimetres or over | 1.43 (0.84–4.06) | 1.19 (1.03–1.38) | 1.71 (0.85–3.44) | 32.4 |
| Waist-to-height ratio | ||||
| 0.5 or over | 1.43 (0.70–2.93) | 1.09 (0.97–1.21) | 1.56 (0.76–3.20) | 19.4 |
| 0.6 or over | 1.34 (0.63–2.88) | 1.16 (0.96–1.42) | 1.57 (0.76–3.27) | 32.9 |
Adjusted for baseline age, residence, education, income, leisure physical activity, smoking and drinking status, consumption of fruits and vegetables, consumption of deep fried food, and hypertension.
*Proportion mediation=log(ORNIE)/log(ORTE) × 100% where NIE represents the natural indirect effect and TE represents the total effect.