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. 2017 Jun 12;6(6):e348. doi: 10.1038/oncsis.2017.45

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Copyright © 2017 The Author(s)

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Detection of USP17, HAS2 and hyaluronan in non-small cell lung cancer (NSCLC) tissue. (a) Immunohistochemical stainings of USP17, HAS2 and hyaluronan in normal lung tissue (a–c), lung tissue showing dysplasia (d–f), SqCC (g–i) and acinar ADC (j–l). Arrows indicate cellular expression in epithelial cells of pre-neoplastic and neoplastic tissue, and asterisks indicate expression in stromal cells. Scale bar: 200 μm. (b) Immunofluorescence staining of USP17 and hyaluronan using specific anti-USP17 antibodies and a biotinylated globular domain of aggrecan, respectively, in SqCC (a–c) and acinar ADC (d–f). Arrows indicate cellular staining foci cell–stroma interface, asterisks indicate stromal tissue signal. Scale bar: 100 μm.