Table 1. Staining intensity of USP17, HAS2 and hyaluronan in pre-neoplastic and neoplastic lung tissue.
| Antigens | Pre-neoplastic tissue | Neoplastic lesion | Intensity (means±s.d.a) | P-value compared to normal |
|---|---|---|---|---|
| USP17 | ||||
| Normal | 29.9±16.3 | |||
| Dysplasia | 68.3±22.3 | 0.005 | ||
| SqCC | 15.8±15.0 | 0.06 | ||
| ADC | 82.6±12.0 | 0.001 | ||
| HAS2 | ||||
| Normal | 16.5±8.5 | |||
| Dysplasia | 75.1±9.4 | 0.01 | ||
| SqCC | 17.7±17.4 | >0.5 | ||
| ADC | 89.5±18.2 | 0.001 | ||
| Hyaluronan | ||||
| Normal | 25.2±10.5 | |||
| Dysplasia | 32.4±13.5 | 0.09 | ||
| SqCC | 42.9±12.4 | 0.05 | ||
| ADC | 58.0±14.4 | 0.02 | ||
Abbreviations: ACIS, Automated Cellular Imaging System; ADC, acinar adenocarcinoma; SqCC, squamous cell carcinoma.
SqCC, n=25; ADC, n=31; normal, n=12; dysplasia, n=10.
a
Calculated with the software ACIS III as described.63 A P-value<0.05 was considered to be significant.