Table 1.

Studies in which a pool of coilin (in all or a subset of cells) was detected in or surrounding the nucleolus. KO = knockout; K_D = knockdown.

A. Coilin detected in nucleolus
Condition	Cell line(s)	Reference
Neuronal cells	Rat primary neurons	6
Hibernating dormice	Dormouse liver sections	29
Breast cancer cells	Hep2, MOT4, HBL100, T47D, MCF7	30
Inhibition of serine/threonine phosphatase activity	HeLa	28
Inhibition of CRM1-dependent nuclear export	HeLa	19
Coilin truncation mutants lacking C-terminus (1–248 and 1–315)	HeLa	25
High overexpression of exogenous coilin	MEFs (coilin KO), HeLa	33
Depletion of SMN	HeLa	22, 27, 32
Depletion of the methyltransferase TGS1	HeLa	27
Depletion of the FLICE-associated huge protein FLASH	SAOS2, IMR90, HeLa, MCF7, MEFs	16
Nonphosphorylatable coilin mutants	HeLa (normal and coilin KD), WI38	24
Hypomethylated coilin	MCF7MTAP−/−, HeLa	34
Depletion of the telomerase complex member WRAP53	U2OS, HeLa	36
Pcd (Purkinje cell degeneration) ataxia mouse model	Mouse primary neurons	37
SMA motor neurons	Human primary motor neurons	35
Depletion of the SUMO isopeptidase USPL1	HeLa, U2OS	26
B. Coilin detected in perinucleolar caps
Condition	Cell line(s)	Reference
Inhibition of RNA transcription	HeLa	18
Coilin truncation mutant lacking N- and C-termini (94–291)	HeLa	17
Depletion of SMN	HeLa	23, 32
Inhibition of RNA transcription	HeLa, U2OS	31
UVC-induced DNA damage	Various mammalian lines	20
Depletion of PRMT5 or PRMT7	HeLa	23
Cisplatin or gamma-irradiation-induced DNA damage	HeLa, WI38, SAOS2	21