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Modifications and modifiers of coilin, the CB marker protein. Enzymes known to modify coilin are shown. Not shown are coilin proteins with multiple different PTMs. During mitosis, coilin is hyperphosphorylated (coilin with 6 phosphorylations), which correlates with decreased coilin self-association and disassembled CBs. Hypomethylated coilin, which is enriched within the nucleolus, is indicated. Also shown in the nucleolus is a coilin phosphomutant (S184A). More details in text.
