Figure 7.

W2476 improves glucose homeostasis and insulin sensitivity in DIO mice. Male C57BL/6 mice fed on SCD or HFD for 12 weeks were chronically treated with W2476 (200 or 400 mg·kg⁻¹·d⁻¹), verapamil (100 mg·kg⁻¹·d⁻¹) or vehicle for 6 weeks (n=9 per group). (A) Body weight at the end of treatment. (B) Average daily food intake during the 6-week treatment period. (C) The 6-h fasting blood glucose levels at weeks 0, 3 and 6. (D) Plasma insulin levels following 6-week treatment. At the end of the experiment, ITT was carried out to measure blood glucose response (E) and associated AUC_0–120 (F) in each group. Data shown are mean±SEM. ^*P<0.05, ^**P<0.01 vsSCD group. ^#P<0.05, ^##P<0.01 vs HFD group.