Table 3. Correlation between structural parameters (macular and retinal nerve fiber layer thickness) and contrast sensitivity vision (CSV) evaluated with Pelli-Robson and CSV-1000E tests in patients with Alzheimer's disease.
CSV-1000E TEST |
Pelli Robson |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
6 CPD | P-value | 9 CPD | P-value | 12 CPD | P-value | 18 CPD | P-value | R | P-value | |
Macular thickness | ||||||||||
Fovea | 0.043 | 0.770 | 0.19 | 0.900 | 0.45 | 0.760 | 0.14 | 0.330 | −0.02 | 0.881 |
Inner superior sector | 0.43 | 0.030 | 0.35 | 0.010 | 0.44 | 0.020 | 0.43 | 0.030 | 0.45 | <0.001* |
Inner nasal sector | 0.48 | 0.010 | 0.37 | 0.010 | 0.44 | 0.020 | 0.43 | 0.040 | 0.48 | <0.001* |
Inner inferior sector | 0.34 | 0.020 | 0.28 | 0.050 | 0.40 | <0.001* | 0.38 | 0.010 | 0.47 | <0.001* |
Inner temporal sector | 0.42 | 0.030 | 0.23 | 0.110 | 0.36 | 0.010 | 0.44 | <0.001* | 0.43 | <0.001* |
Outer superior sector | 0.50 | <0.001* | 0.36 | 0.010 | 0.57 | <0.001* | 0.50 | <0.001* | 0.65 | <0.001* |
Outer nasal sector | 0.50 | <0.001* | 0.50 | <0.001* | 0.49 | <0.001* | 0.50 | <0.001* | 0.58 | <0.001* |
Outer inferior sector | 0.17 | 0.240 | 0.27 | 0.050 | 0.38 | <0.001* | 0.32 | 0.030 | 0.38 | <0.001* |
Outer temporal sector | 0.47 | <0.001* | 0.22 | 0.120 | 0.50 | <0.001* | 0.39 | <0.001* | 0.66 | <0.001* |
Average thickness | 0.43 | 0.090 | 0.21 | 0.420 | 0.56 | 0.030 | 0.53 | 0.050 | 0.63 | <0.001* |
Macular volume | 0.48 | 0.050 | 0.34 | 0.150 | 0.30 | 0.240 | 0.27 | 0.320 | 0.54 | 0.010 |
Rnfl thickness | ||||||||||
Average | 0.41 | 0.040 | 0.33 | 0.020 | 0.43 | <0.001* | 0.40 | <0.001* | 0.46 | <0.001* |
Superior quadrant | 0.31 | 0.030 | 0.23 | 0.040 | 0.46 | <0.001* | 0.41 | <0.001* | 0.46 | <0.001* |
Nasal quadrant | 0.37 | 0.010* | 0.19 | 0.200 | 0.20 | 0.190 | 0.11 | 0.440 | 0.37 | 0.010* |
Inferior quadrant | 0.22 | 0.140 | 0.11 | 0.440 | 0.23 | 0.120 | 0.23 | 0.110 | 0.22 | 0.140 |
Temporal quadrant | 0.23 | 0.110 | 0.35 | 0.010* | 0.26 | 0.740 | 0.35 | 0.010* | 0.12 | 0.410 |
Abbreviations: CSV, contrast sensitivity vision; RNFL, retinal nerve fiber layer.
Data in bold correspond to statistically significant correlations (P-value <0.05). Asterisk indicates a significant difference by Pearson’s test after Bonferroni's correction for multiple tests (P≤0.0045 for macular thickness; P≤0.010 for RNFL thickness).