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. Author manuscript; available in PMC: 2018 Feb 22.
Published in final edited form as: J Am Chem Soc. 2017 Feb 7;139(7):2532–2540. doi: 10.1021/jacs.6b10646

Figure 2.

Figure 2

Schematic of cell-SELEX and strategy of aptamer-based cell surface biomarker discovery. (A) Cell-SELEX technology selects a panel of aptamers capable of distinguishing molecular differences between two types of cells. Aptamers are selected to bind with target cells, but not counter cells. (B) Aptamer-assisted affinity purification without cross-linking aptamers and target proteins as targeted proteomics strategy for cancer cell surface biomarker discovery. (C) Aptamer-assisted affinity purification with cross-linking aptamers and target proteins as targeted proteomics strategy for cancer cell surface biomarker discovery.