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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Dev Biol. 2017 May 10;427(1):72–83. doi: 10.1016/j.ydbio.2017.05.005

Fig. 7.

Fig. 7

In conclusion, Osr1 functions downstream of HH pathway and regulate multiple aspects of foregut development. (A) during lobulation, Osr1, which expression is restricted in the medial mesenchyme, prevents medial/anterior shifting of cranial lobe; (B) during trachea and esophagus mesenchyme differentiation, Osr1 is expressed in the peripheral mesenchyme surrounding trachea and esophagus, supporting esophagus and trachea smooth muscle differentiation, trachea cartilage ring formation and pulmonary arteries development. Blue spaces indicate Osr1 expression domains; red dotted line outlines the splanchnic mesenchyme. Yellow marks the endoderm; red spaces mark esophageal smooth muscle in the dorsal and tracheal smooth muscle in the ventral; green space marks the cartilage; red circles show pulmonary artery smooth muscle. D, dorsal; V, ventral; A, anterior; P, posterior.