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. Author manuscript; available in PMC: 2017 Jul 20.
Published in final edited form as: Dev Cell. 2016 Nov 3;39(4):452–465. doi: 10.1016/j.devcel.2016.09.027

Figure 6. DNA damage/senescence signature is present in benign NF2-associated schwannomas and meningiomas, but not in NF2 mutant malignant mesotheliomas.

Figure 6

(A) GSEA by comparing a high-confidence senescence associated gene set with published datasets of human schwannomas (GSE39645) (Torres-Martin et al., 2013), meginingiomas (GSE43290 and GSE58037) (Clark et al., 2013; Tabernero et al., 2009), or mesotheliomas (GSE29354) (Bott et al., 2011) as indicated.

(B) Representative images of pH2AX IHC of five schwannomas (S1–S5) and one meningiomas (M) from NF2 patients, and of uteri from 15-month-old P0-Cre;Nf2flox/flox (Nf2KO) and WT mice.

See also Figure S6, and Table S1.