Figure 5. Patterns of recombination near TSSs and CGIs in species with and without complete PRDM9 orthologs.
For each species, recombination rates were binned in 10 kb windows along the genome; curves were fit using gaussian loess smoothing. The fold change in recombination rates shown on the y-axis is relative to recombination rates at the last point shown. Species shown in the top row have complete PRDM9 orthologs (mouse, human, gorilla and sheep), whereas species in the bottom row have no PRDM9 ortholog (dog, zebra finch, long-tailed finch), or a partial PRDM9 ortholog (swordtail fish).
Figure 5—figure supplement 1. Dependence of patterns of recombination near TSSs and CGIs in dog and human on the type of genetic map.
(a) Recombination rates near the TSS and CGI in dogs are shown using recombination maps inferred either from LD patterns or pedigree data. The magnitude of the peak near these features is lower in the map with lower resolution. This observation raises the possibility that a higher resolution map in swordtail fish would result in a higher peak near these features. (b) Recombination rates near the TSS and CGI in humans are shown using recombination maps inferred either from LD patterns or ancestry switches in African-American samples. Recombination rates near the TSS and CGI in human do not seem to be strongly influenced by the choice of genetic map, though peaks at these features are slightly reduced in admixture- and pedigree-based methods.