Figure 1.

Short-term treatment with INT-767 reverses age-related kidney disease. A and B, caloric restriction prevents age-related decreases in renal FXR and TGR5 expression. C, INT-767 induces a significant decrease in urinary albumin like lifelong caloric restriction. D, INT-767 prevents the age-related decrease in synaptopodin expression as determined by immunofluorescence microscopy. E, INT-767 prevents the age-related increases in TGF-β, fibroblast specific protein-1 (FSP-1), and fibronectin mRNA. F, age-related increase in fibronectin protein expression as determined by immunofluorescence microscopy is prevented by INT-767 treatment. Error bars represent S.D. n = 6 mice. *, p < 0.05 versus 5-month-old ad libitum fed (5mo-AL); **, p < 0.05 versus 24-month-old ad libitum fed (24mo-AL). INT, INT-767-treated; CR, calorie-restricted; pAMPK, phospho-AMPK.