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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Am J Transplant. 2017 Mar 13;17(8):2045–2054. doi: 10.1111/ajt.14227

Figure 2. Polyfunctional CMV-responsive CD8+ T cells tend to be terminally differentiated effectors.

Figure 2

A) Total and polyfunctional CD8+ T cells were gated for CCR7 and CD45RO expression. B) Proportion of polyfunctional CD8+ T cells in each memory/effector subpopulation pre-transplant. Bars stack to a total of 100% of polyfunctional cells. n=15. C) Proportion of polyfunctional CD8+ T cells that are effector (CD45RO−CCR7−, black squares) or effector memory (CD45RO+CCR7−, gray triangles) phenotype in response to IE-1 or pp65. Trends analyzed using mixed-effects generalized linear modeling in STATA. There were no statistically significant differences. Lines represent means and error bars represent SEM. # PT represents the number of patients at each time point. Not all recipients had samples at all time points, resulting in variable n.