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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Hepatology. 2017 Jun 26;66(2):321–323. doi: 10.1002/hep.29227

Figure 1. MiRNAs play important roles in the control of ALD development and progression in cell-specific manners.

Figure 1

For example, miR-181b-3p acts as anti-inflammatory mediator to inhibit Kupffer cell activation; whereas miR-155 promotes Kupffer cell activation. Ethanol downregulates miR-181b-3p in Kupffer cells, thereby inducing Kupffer cell activation. Treatment of HA35 normalizes ethanol-induced miR-181b-3p downregulation in Kupffer cells and subsequently ameliorates ethanol-induced liver injury and inflammation.