Table 1.

Diagnostic criteria for CFLD by the Debray criteria and the new criteria.

Categories	Debray Criteria^	New Criteria
Diagnosis of CFLD should be considered if 1 of the following is present:
		Liver biopsy demonstrating pathology or radiologic evidence demonstrating diffuse liver disease or cirrhosis.
Diagnosis of CFLD should be considered if ≥2 categories are present:
Physical Examination	Hepatomegaly: >2 cm below the costal margin on the mid-clavicular line, confirmed by ultrasonography And/or splenomegaly, confirmed by US	Not included
Serum Blood Tests	Increase of transaminases and GGT above upper limits of normal at least 3 consecutive determinations over 12 months after excluding other causes of liver disease.	At least 2 persistently abnormal* ALT, AST, GGT or ALP
Radiologic Testing	Ultrasonographic evidence of liver involvement or portal hypertension or biliary abnormalities	Evidence of hepatomegaly, splenomegaly, or portal hypertension by imaging
Liver Biopsy	May be indicated if there is diagnostic doubt
Vibration Controlled Transient Elastography	Not included	Abnormal fibroscan at any time
Noninvasive Fibrosis Biomarker Assessment	Not Included	Persistently abnormal* APRI, FIB-4, or AAR

^*Persistently abnormal was defined as having abnormal values on multiple dates over at least 2 consecutive years.

^{^}Diagnostic criteria for CFLD as described by Debray et al.¹²