Table 3.
Median laboratory values (with interquartile ranges) for the first two years of follow-up and the last two year of follow-up in subjects classified as CFLD and no CFLD by the Debray criteria
| Biomarker | CFLD n=8 (22%) |
No CFLD n=28 (88%) |
p-value |
|---|---|---|---|
| First Two Years of Follow-up | |||
| AST (U/L) | 28 (26,34) | 23 (20,28) | 0.37 |
| ALT (U/L) | 34 (25,41) | 21 (18,39) | 0.51 |
| Alkaline Phosphatase (U/L) | 182(167, 274) | 127(97, 203) | 0.11 |
| Platelets (K/uL) | 331 (281, 403) | 284 (237, 354) | 0.38 |
| Total Bilirubin | 0.53 (0.39, 0.93) | 0.38 (0.32, 0.47) | 0.18 |
| Direct Bilirubin | 0.10 (0.05,0.10) | 0.10 (0.05,0.10) | 0.59 |
| PT | 12.4 (12.3, 13.4) | 12.5 (11.6, 13.1) | 0.71 |
| Albumin | 3.9 (3.6, 4.2) | 4.1(4.0, 4.5) | 0.05 |
| APRI | 0.18 (0.16,0.35) | 0.21 (0.13,0.25) | 0.81 |
| FIB4 | 0.19 (0.12,0.35) | 0.39 (0.25,0.62) | 0.14 |
| AST/ALT Ratio | 0.78 (0.70,1.02) | 1.01 (0.74,1.28) | 0.09 |
| Last Two Years of Follow-up | |||
| AST (U/L) | 25 (21,32) | 34(25,41) | 0.98 |
| ALT (U/L) | 39 (31, 48) | 30 (23,41) | 0.22 |
| ALP (U/L) | 128 (96,187) | 107 (91, 122) | 0.24 |
| Platelets (K/uL) | 260 (165,283) | 270 (223,302) | 0.23 |
| Total Bilirubin (mg/dL) | 0.60 (0.53,0.88) | 0.38 (0.35,0.44) | 0.08 |
| Direct Bilirubin (mg/dL) | 0.18(0.14, 0.32) | 0.1(0.10, 0.12) | 0.06 |
| PT (sec) | 14.3 (13.7,14.9) | 13.9 (12.2,14.1) | 0.21 |
| Albumin (g/dL) | 3.5 (3.4, 3.7) | 3.7 (3.5, 4.0) | 0.10 |
| APRI | 0.31 (0.22,0.61) | 0.23 (0.19,0.33) | 0.25 |
| FIB-4 | 0.73 (0.48,1.72) | 0.77 (0.57,1.02) | 0.36 |
| AST/ALT Ratio | 0.78 (0.65,1.09) | 1.12 (0.80, 1.35) | 0.21 |
| Transient Elastography (kPa) (n=24) | 3.9 (3.4, 42.2) (n=7) | 4.65 (3.8, 7.2) (n=17) | 0.23 |