Table 4.

Median laboratory values (with interquartile range) for the first two years of follow-up and last two years of follow-up in subjects classified as CFLD and no CFLD by new criteria.

Biomarker	CFLD n=17 (47%)	No CFLD n=19 (53%)	p-value
First Two Years of Follow-up
AST (U/L)	32 (22,46)	21 (17,33)	0.3
ALT (U/L)	28 (22,35)	23 (19,27)	0.065
Alkaline Phosphatase (U/L)	184 (148, 270)	115 (89, 152)	0.02
Platelets (K/uL)	306 (241, 367)	285 (229, 357)	0.9
Total Bilirubin	0.45 (0.26, 0.6)	0.43 (0.33, 0.49)	0.4
Direct Bilirubin	0.1 (0.04, 0.13)	0.1 (0.05, 0.1)	0.36
PT	12.4 (11.8, 13.2)	12.5 (11.2, 13.2)	0.96
Albumin	4.2 (3.8, 4.4)	4.0 (3.9, 4.3)	0.98
APRI	0.20 (0.15,0.34)	0.19 (0.12,0.24)	0.33
FIB4	0.24 (0.17,0.60)	0.45 (0.25,0.72)	0.11
AST/ALT Ratio	0.59 (0.53,0.92)	0.88 (0.62,1.07)	0.15
Last Two Years of Follow-up
AST (U/L)	26 (21,33)	21 (17,26)	0.01
ALT (U/L)	42 (29, 53)	27 (20,34)	0.005
ALP (U/L)	110 (94,132)	107 (83, 129)	0.17
Platelets (K/uL)	241 (179,286)	274 (223,315)	0.10
Total Bilirubin (mg/dL)	0.45 (0.35,0.64)	0.40 (0.32,0.45)	0.14
Direct Bilirubin (mg/dL)	0.13 (0.10,0.17)	0.10 (0.10,0.11)	0.01
PT (sec)	14.4 (13.2,15.2)	12.4 (11.9,13.9)	0.002
Albumin (g/dL)	3.6 (3.5,3.9)	3.6 (3.4,4.1)	0.36
APRI	0.34 (0.22,0.54)	0.20 (0.17,0.23)	0.003
FIB-4	0.78 (0.59,1.33)	0.70 (0.50,1.00)	0.08
AST/ALT Ratio	0.78 (0.65,1.09)	1.12 (0.80, 1.35)	0.18
Transient Elastography (kPa) (n=24)	5.4 (3.3, 10.0) (n=15)	4 (3.3, 4.8) (n=9)	0.34