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. Author manuscript; available in PMC: 2017 Sep 8.
Published in final edited form as: Adv Drug Deliv Rev. 2017 Jan 20;116:73–91. doi: 10.1016/j.addr.2017.01.005

Figure 1. Transport of S-1,2,-dichlorovinyl-L-cysteine (DCVC) and N-acetyl-DCVC.

Figure 1

Organic anion transporter 1 (OAT1) transports DCVC and N-acetyl-DCVC across the basolateral membrane of proximal tubules while amino acid transporters, such as system ASC, A, and L, reabsorb the metabolites of trichlorethylene on the apical surface. N-acetyl-DCVC is removed from renal cells by multidrug resistance-associated protein 2 (MRP2), whereas DCVC is not.