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. Author manuscript; available in PMC: 2017 Sep 8.
Published in final edited form as: Adv Drug Deliv Rev. 2017 Jan 20;116:73–91. doi: 10.1016/j.addr.2017.01.005

Figure 2. Transport of Paraquat.

Figure 2

Organic cation transporter 2 (OCT2) is primarily responsible for the accumulation of paraquat (PQ) in proximal tubules whereby redox cycling results in toxicity. Efflux of PQ takes place through the multidrug and toxin extrusion protein 1 (MATE1) and multidrug resistance protein 1 (MDR1).