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. Author manuscript; available in PMC: 2017 Sep 8.
Published in final edited form as: Adv Drug Deliv Rev. 2017 Jan 20;116:73–91. doi: 10.1016/j.addr.2017.01.005

Figure 5. Transport of Mercury.

Figure 5

Mercury (Hg2+) and methylmercury (CH3Hg2+) bind to sulfhydryl groups including thiol-containing molecules such as glutathione (GSH), cysteine (Cys), homocysteine (Hcy), and N-acetylcysteine (NAC). These conjugated mercury species are taken up basolaterally by organic anion transporters (OAT) and apically by amino acid transporters including L -cysteine, system B0,+, and Na+-dependent low-affinity L -systems. Efflux transporters on the brush border membrane include multidrug resistance-associated protein 2 (MRP2) and breast cancer resistance protein (BCRP).