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. Author manuscript; available in PMC: 2017 Sep 8.
Published in final edited form as: Adv Drug Deliv Rev. 2017 Jan 20;116:73–91. doi: 10.1016/j.addr.2017.01.005

Figure 8. Transport of Cisplatin.

Figure 8

Cisplatin is taken up into the proximal tubules by the organic cation transporter 2 (OCT2) and also possibly by copper transporter 1 (CTR1). Cisplatin is removed by efflux using the multidrug and toxin extrusion protein 1 (MATE1). Cisplatin also further conjugates with glutathione (GSH) in the proximal tubules and has been proposed to undergo secretion by the multidrug resistance-associated protein 2 (MRP2).