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. 2017 Jul 21;8:164. doi: 10.3389/fendo.2017.00164

Figure 7.

Figure 7

(A) Percent area of TPH2 mRNA expression in the dorsal raphe (DR) decreased with maternal high-fat diet (HFD) exposure (F1,35 = 5.260, p = 0.028). (B) Controlling for offspring glucose area under curve (GAUC), expression in the median raphe (MnR) increased with postweaning HFD exposure (F1,26 = 7.675, p = 0.010). (C) Offspring GAUC itself increased with MnR TPH2 mRNA expression (F1,26 = 9.719, p = 0.004). (D) Representative images of the differences seen in TPH2 mRNA Expression in the DR between the four diet groups. Data shown as mean ± SEM. * denotes maternal diet effect and # denotes a postweaning diet effect, p < 0.05. Magenta lines denote significant overall covariance, p < 0.05. Scale bars are 200 µm. Sample sizes for TPH2 mRNA expression are as follows: DR: CTR/CTR n = 15 (n = 9 males; n = 6 females), CTR/HFD n = 8 (n = 4 males; n = 4 females), HFD/CTR n = 8 (n = 5 males; n = 3 females), and HFD/HFD n = 12 (n = 8 males; n = 4 females) and MnR: CTR/CTR n = 13 (n = 7 males; n = 6 females), CTR/HFD n = 7 (n = 3 males; n = 4 females), HFD/CTR n = 7 (n = 4 males; n = 3 females), and HFD/HFD n = 8 (n = 5 males; n = 3 females).