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Details of predicted in silico ADMET risk range and risk parameters of compound P-902 and standard anticancer drug topotecan.
| Risk | Absorption | P450 oxidation | Mutagenicity | Toxicity | ADMET Risk | Risk Parameters |
|---|---|---|---|---|---|---|
| Range | 0–8 | 0–6 | 0–4 | 0–7 | 0–24 | |
| P-902 | 3.26 | 0.0 | 0.0 | 0.96 | 4.22 | Size, charge, water solubility, lipophilicity |
| Topotecan (control) | 0.0 | 0.0 | 2.0 | 2.0 | 2.0 | Hepatotoxicity, inhibition of 3A4 oxidation of midazolam |
