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. 2017 Jul 20;7:5986. doi: 10.1038/s41598-017-06236-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Flt3L^−/− mice and Ccr2^−/− mice show impaired effector T cell responses. Analysis of the effector T cell response to OVA/CpG vaccination. (A–C) Comparison of effector T cell responses between WT and Flt3L^−/− mice. (D–F) Comparison of effector T cell responses between WT and Ccr2^−/− mice. (A,D) ELISPOT analysis determining the numbers of IFN-γ secreting T cells (n = 6; mean +/− SD). (B,E) Flow cytometric quantification of OVA-specific CD8 T cells in blood (n = 5/group; mean +/− SD). (C,F) OVA-specific cytotoxicity as measured by an in vivo killing assay (n = 7/group; mean +/− SD). ****P < 0.0001, ***p < 0.001. Data shown are representative of three independent experiments.