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. 2017 Jul 21;10:226. doi: 10.3389/fnmol.2017.00226

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Copyright © 2017 Yang, Luo, Sun, Wang, Wang, Yang, Li, Wei, Wang, Guan and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of intra-thalamic AMD3100 injection on the induction and maintenance of ITC-induced CPSP. (A) Temporal pattern of effects of intra-thalamic AMD3100 (15 μg/μl) injection at 30 min before ITC on the induction of bilateral mechanical pain hypersensitivity. *P < 0.05, IT-AMD vs. IT-Veh; n = 10/group. (B) Temporal pattern of effects of intra-thalamic AMD3100 (7.5 and 15 μg/μl) injection at 10 days post thalamic hemorrhage on the established bilateral mechanical pain hypersensitivity. *P < 0.05, ***P < 0.001, ITC-AMD 15 vs. ITC-Veh; ^#P < 0.05, ^###P < 0.001, ITC-AMD 7.5 vs. ITC-Veh; n = 10/group. (C) Quantification of area under the analgesic effects of AMD3100 (7.5 and 15 μg/μl). ***P < 0.001 vs. ITC-Veh; ^###P < 0.001 vs. ITC-Veh; PWMT, paw-withdrawal mechanical threshold.