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. 2017 Jul 21;10:226. doi: 10.3389/fnmol.2017.00226

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Copyright © 2017 Yang, Luo, Sun, Wang, Wang, Yang, Li, Wei, Wang, Guan and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Temporal pattern of hypoxia inducible factor 1α (HIF-1α) expression in peri-thalamic lesion sites following thalamic hemorrhage and effects of intra-thalamic YC-1 injection on the induction and maintenance of CPSP. (A) Western blot assay showing the time course expression of HIF-1α following thalamic hemorrhage. Representative bands are shown on the left, and data summary is shown on the right. *P < 0.05, **P < 0.01 vs. ITS-7 d; n = 4/group. (B) Effect of intra-thalamic pre-injection of YC-1 (0.2 mM, 1 μl) on the induction of bilateral mechanical pain induced by thalamic hemorrhage. **P < 0.01, ***P < 0.001 IT-YC1 vs. IT-Veh; n = 7/group. (C) Effect of intra-thalamic YC-1 injection at 10 days post thalamic hemorrhage on the established bilateral mechanical pain. n = 7/group. PWMT, paw-withdrawal mechanical threshold.