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. 2017 Jul 20;7:5952. doi: 10.1038/s41598-017-06416-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Microgravity significantly increases Sub-G0 population. Microgravity alters Cell cycle in colorectal cancer cells. The individual histogram of the Propidium iodide staining in cells counted through Flow cytometer (a–f), shows clear shift towards Sub-G0 population in SM colorectal cancer cells DLD1, HCT116 and SW620 (b,d,f) respectively, compared to the respective controls (a,c,e). The graphical representation of the population shift during microgravity (g) in mean + S.D., Sub-G0 and G0-G1 shift in DLD1 was highly significant P < 0.0005, compared to HCT116 P < 0.05 and SW620 P < 0.005. The experiment was performed a minimum of three times with individual controls. qPCR analysis of Gene expression for CDK7, CCNG2, CCNT2, CDKN2B and CDKN2D genes between DLD1 cells subjected to SM and shifted to normal (SS) with GAPDH as housekeeping control (e), represented in log fold change of mean + S.D. *P < 0.05. The experiments were performed three times with individual controls.