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. 2017 Jul 20;7:5961. doi: 10.1038/s41598-017-05700-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Imaging of mice bearing A431 xenografts. PET/CT using ⁶⁸Ga-DOTA-Z_EGFR:2377 at 3 h after injection (a) and SPECT/CT using ⁵⁷Co-DOTA-Z_EGFR:2377 at 3 h (b) and 24 h (c) after injection. The images show three-dimensional volume rendering of PET or SPECT data overlaid CT data. The images were rotated to provide view of liver. The relative colour scales were normalized to the highest activity and then adjusted to provide first red pixel in tumours (8, 13 and 17% of the full scale, for Fig. 4a,b and c, respectively). Arrows point at tumours (Tu), kidneys (Ki) and livers (Li).