Table 2.

Tumour-to-organ ratios of ⁶⁸Ga-DOTA-Z_EGFR:2377 and ⁵⁷Co-DOTA-Z_EGFR:2377 after injection of 40 μg into BALB/C nu/nu mice bearing A431 xenografts.

	3 h after injection		24 h after injection
	68Ga-DOTA-ZEGFR:2377	57Co-DOTA-ZEGFR:2377	57Co-DOTA-ZEGFR:2377
Blood	7 ± 2a	12 ± 2	32 ± 7b
Salivary gland	7.3 ± 0.4a	10 ± 2	10.2 ± 0.8
Lung	5.9 ± 0.7a	10 ± 2	11 ± 1
Liver	0.44 ± 0.03a	3.1 ± 0.5	3.3 ± 0.3
Spleen	1.5 ± 0.4a	13.9 ± 0.7	11 ± 1b
Colon	7.1 ± 0.8a	10 ± 1	9 ± 1
Kidney	0.013 ± 0.002a	0.023 ± 0.002	0.019 ± 0.001b
Muscle	26 ± 3a	56 ± 10	48 ± 7
Bone	12 ± 2a	24 ± 5	21 ± 5

Data are average of four animals ± SD.

^aSignificant (p < 0.05) difference between ⁶⁸Ga-DOTA-Z_EGFR:2377 and ⁵⁷Co-DOTA-Z_EGFR:2377.

^bSignificant (p < 0.05) difference between values for ⁵⁷Co-DOTA-Z_EGFR:2377 at 3 and 24 h after injection.