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RgIA4 IC50 values for various nAChR subtypes.
| nAChR Subtype | IC50 (nM) |
|---|---|
| α1β1δϵ | >10,000 |
| α1β1δγ | >10,000 |
| α2β2 | >10,000 |
| α3β2 | >10,000 |
| α3β4 | >10,000 |
| α4β2 | >10,000 |
| α4β4 | >10,000 |
| α7 | 4,500 |
| α9α10 | 1.2 |
Xenopus laevis oocytes were injected with nAChR subunits to express the indicated subtypes. RgIA4 was then applied to the oocytes expressing the nAChR subtypes and the response to ACh was assessed.
