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. 2017 Jul 20;7:5964. doi: 10.1038/s41598-017-06549-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Three-dimensional image of the EGFP-positive conceptus in the uterus of wild-type mice. The EGFP-positive conceptus in the EGFP-negative uterus of wild-type mice was created by mating CAG-EGFP male mice with wild-type ICR female mice. Pregnant mice were transcardially perfused with 4% PFA and PI solution at E10.5. After the isolated reproductive organs were subjected to CUBIC, 3D and cross-sectional images of the EGFP-positive conceptus in the EGFP-negative uterus of wild-type mice were taken using a light-sheet microscope. A whole 3D image (a) and a sectional image within a blue square of the left panel (b) are shown. Note that fluorescence was clearly visible in the EGFP-positive conceptus, including the placenta and embryo. Scale bars, 1 mm.