Table 3.
Prevalence of patients with dementia without a psychosis diagnosis receiving repeated antipsychotic drug prescriptions between 1 January, and 30 June, 2014 and unadjusted and adjusted odds ratios from a two-level logistic regression model with random effects at the practice level
| Variable | Observed prevalence (%) | Unadjusted odds ratio (95% CI) | Adjusted odds ratio (95% CI) |
|---|---|---|---|
| Age, years | |||
| 65–70 | 138/1181 (11.7) | 1 (reference) | 1 (reference) |
| 71–75 | 232/2236 (10.4) | 0.88 (0.70–1.11) | 0.86 (0.68–1.09) |
| 76–80 | 350/4007 (8.7) | 0.73 (0.59–0.91) | 0.70 (0.56–0.87) |
| 81–85 | 448/5764 (7.8) | 0.64 (0.52–0.79) | 0.61 (0.49–0.75) |
| >85 | 712/9453 (7.5) | 0.62 (0.51–0.75) | 0.58 (0.48–0.71) |
| Number of medications on repeat prescriptions in the previous 12 months (excluding antipsychotic drugs) | |||
| 0–5 | 439/7519 (5.8) | 1 (reference) | 1 (reference) |
| 6–9 | 472/6121 (7.7) | 1.47 (1.27–1.71) | 1.47 (1.27–1.70) |
| 10–14 | 547/5450 (10.0) | 1.94 (1.68–2.25) | 1.96 (1.69–2.26) |
| 15 or more | 422/3551 (11.9) | 2.33 (2.00–2.73) | 2.31 (1.98–2.70) |
| Sex | |||
| Male | 647/7857 (8.2) | 1 (reference) | 1 (reference) |
| Female | 1233/14784 (8.3) | 1.00 (0.90–1.11) | 1.06 (0.95–1.17) |
| List size (quartiles) | |||
| <5000 | 202/2438 (8.3) | 1 (reference) | 1 (reference) |
| 5000 to <8000 | 440/5197 (8.5) | 1.06 (0.8–1.38) | 0.96 (0.75–1.22) |
| 8000 to <11,000 | 587/7253 (8.1) | 1.04 (0.80–1.35) | 0.97 (0.76–1.24) |
| >11,000 | 651/7753 (8.4) | 1.07 (0.82–1.39) | 1.10 (0.86–1.42) |
| Proportion (%) of patients in practice aged 65 years or over (CPRD mean = 19.6%) | |||
| <15 | 289/3409 (8.5) | 1 (reference) | 1 (reference) |
| 15 to <20 | 733/8181 (9.0) | 1.14 (0.90–1.45) | 1.04 (0.83–1.31) |
| 20 to <25 | 632/7565 (8.4) | 1.06 (0.83–1.36) | 0.95 (0.75–1.21) |
| >25 | 226/3486 (6.5) | 0.84 (0.61–1.15) | 0.82 (0.60–1.12) |
| Practice level index of multiple deprivation | |||
| 1 least deprived | 409/4801 (8.5) | 1 (reference) | 1 (reference) |
| 2 | 415/4578 (9.1) | 1.07 (0.82 1.40) | 1.24 (0.97–1.59) |
| 3 | 386/4723 (8.2) | 0.99 (0.76–1.29) | 1.16 (0.90–1.49) |
| 4 | 371/4767 (7.8) | 1.04 (0.80–1.36) | 1.09 (0.85–1.40) |
| 5 most deprived | 299/3772 (7.9) | 0.99 (0.75–1.30) | 0.96 (0.73–1.25) |
| Region | |||
| North West | 204/2309 (8.8) | 1 (reference) | 1 (reference) |
| North East | 6/202 (3.0) | 0.29 (0.10–0.82) | 0.30 (0.11–0.86) |
| Yorkshire/Humber | 15/251 (6.0) | 0.69 (0.31–1.53) | 0.71 (0.32–1.59) |
| West Midlands | 175/1994 (8.8) | 0.96 (0.68–1.35) | 1.05 (0.74–1.50) |
| East of England | 126/1380 (9.1) | 1.00 (0.69–1.45) | 1.06 (0.72–1.56) |
| South West | 110/1888 (5.8) | 0.58 (0.40–0.84) | 0.61 (0.41–0.90) |
| South central | 203/3270 (6.2) | 0.63 (0.46–0.87) | 0.64 (0.46–0.90) |
| London | 114/2017 (5.7) | 0.57 (0.40–0.80) | 0.56 (0.39–0.80) |
| South East coast | 155/2506 (6.2) | 0.59 (0.43–0.83) | 0.63 (0.45–0.89) |
| Northern Ireland | 166/1137 (14.6) | 1.74 (1.20 to 2.53) | 1.51 (1.03–2.22) |
| Scotland | 342/3516 (9.7) | 1.07 (0.80 to 1.42) | 1.14 (0.85–1.53) |
| Wales | 264/2171 (12.2) | 1.43 (1.05 to 1.94) | 1.55 (1.13–2.11) |
CI confidence interval, CPRD Clinical Practice Research Datalink