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. 2017 Jul 20;7:5968. doi: 10.1038/s41598-017-05448-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Step-by-step illustration of how DES-TOMATO can be used to find relevant candidate genes involved in salinity tolerance by focusing on Na⁺ homeostasis and plasma membrane H⁺-ATPases (in yellow). In the network, the pink octagons represent the “Solanaceae Genes” dictionary. The edge color is distributed across a color spectrum from hot/red (high frequency co-occurrence/strong association) to cold/blue (small number of co-occurrences, weaker association). The numbers on the edges provide the number of publications that link the associated nodes.