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. 2017 Jul 20;7:6086. doi: 10.1038/s41598-017-06410-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PD-1H promotes the commitment of iTreg cells. (A) The transferred iTreg cells from each group (gate on CD45.2⁺CD4⁺) in the EAE model were analysed on Day 13. The spleen and dLN cells were intracellularly stained with pSTAT3 or pSTAT5 with specific mAb. (B) Same as A but phosphorylation of STAT3 and STAT5 on transferred iTreg cells is displayed as plotted value. (C) The DNA methylation status of the CNS2 region was determined by bisulfite sequencing. Each line represents one clone (one DNA strand); open cycle, un-methylated cites; filled circles, methylated cites.