Table 11.

Non-liver-directed therapies: SIGN recommendations

Quality of evidences (SIGN)	Recommendation	Strength of recommendation
B	Cytoreductive surgery and intraperitoneal chemohyperthermia performed in centres of expertise can be attempted in patients with isolated peritoneal carcinomatosis.70	Conditional for
D*	Radiation therapy is efficacious for palliative treatment of bone metastases.	Strong for
D*	Radiation therapy +/- chemotherapy can be used for palliation or with a cytoreductive intent in patients with resectable recurrent disease localised in the pelvis, lymph nodes and lung.	Conditional for

*Panel opinion.

SIGN, Scottish Intercollegiate Guidelines Network.