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. 2017 Apr 12;2(1):e000147. doi: 10.1136/esmoopen-2016-000147

Table 3.

Quality of evidences according to the Scottish Intercollegiate Guidelines Network

A At least one meta-analysis, systematic review or randomised clinical trial classified as 1++ and directly applicable to the target population
Studies classified as 1+ and directly applicable to the target population
B Studies classified as 2++ and directly applicable to the target population
Evidences from studies classified as 1++ or 1+, but not directly applicable to the target population
C Studies classified as 2+ and directly applicable to the target population
Evidences from studies classified as 2++, but not directly applicable to the target population
D Evidence level 3 or 4
Evidences from studies classified as 2+, but not directly applicable to the target population