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DLTs registered during the first 2 weeks of combined treatment of metformin and erlotinib
| Dose level | Dose of metformin (mg) | Dose of erlotinib (mg) | Patients (n) | DLT (patients, n) |
| 1 | 2000 | 150 | 3 | Grade 3 vomiting (1), Grade 3 diarrhoea (1) |
| 2 | 1500 | 150 | 9 | None |
DLT, dose-limiting toxicity.
