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. 2017 Jun 9;81(6):825–836. doi: 10.1002/ana.24947

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© 2017 The Authors. Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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AAV1/2‐A53T‐aSyn injection into the SN leads to widespread expression of pathological A53T‐aSyn that projects into the striatum. (A,B) Representative immunofluorescence double stainings showing expression of A53T‐aSyn (green) and TH⁺ dopaminergic neurons (red) in the SN after 43 days of AAV injection in a (A) stim‐OFF rat of the AAV1/2‐A53T‐aSyn‐treated hemisphere and a (B) stim‐ON AAV1/2‐A53T‐aSyn‐treated rat revealing a widespread A53T‐aSyn expression in the SN of both rats and more surviving TH⁺ cells in the AAV1/2‐A53T‐aSyn stim‐ON brain. (C) No detectable aSyn aggregates in the SN of the untreated side of the AAV1/2‐A53T‐aSyn stim‐ON rat are visible. (D) Coronal whole‐brain slice of a AAV1/2‐A53T‐aSyn stim‐ON rat shows the deposition of aSyn (green) and nigrostriatal dopaminergic projections (red) in the dorsal striatum. AAV = adeno‐associated virus; aSyn = α‐synuclein; SN = substantia nigra; TH = tyrosine hydroxylase.