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. 2017 Jun 23;56(30):8681–8685. doi: 10.1002/anie.201702461

Table 1.

Reduction of 2‐methylcyclohexenone (R)‐2‐methycyclohexanone by TsOYE in NAD(P)H‐free, light‐driven biocatalytic platform employing different molecular photosensitizers.

Photosensitizer (PS) TOF[a] [h−1] Yield[b] [%] TTNPS [b] TTNOYE [b] ee [b] [%]
Eosin Y 118 66.5 106 295 >99 (R)
Erythrosine B 100 73.9 118 328 >99 (R)
Phloxine B 78 45.5 73 202 >99 (R)
Rose Bengal 52 53.1 85 235 >99 (R)
Fluorescein 4.6 9.7 15 43 >99 (R)
Rhodamine B 0 1.1 1.8 5 >99 (R)
Rhodamine 6G 2.4 1.1 1.7 4.9 >99 (R)
FMN 4.8 4.1 6.5 18 >99 (R)

[a] Turnover frequency of photosensitizers determined after 30 min. [b] Determined by GC analysis after 180 min reaction. ee: enantiomeric excess; reaction conditions: 50 μm [PS], 18 μm [TsOYE], 10 mm CaCl2, 8 mm 2‐methylcyclohexenone in a 200 mm TEOA buffer, pH 7.5.