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. 2017 Jun 20;81(6):857–870. doi: 10.1002/ana.24954

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© 2017 The Authors. Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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(A) Association between cerebrospinal fluid (CSF) neurofilament light chain (NfL) and serum neurofilament light chain (sNfL) levels in the Lugano cohort. A 10% increase in CSF NfL corresponds to an increase of approximately 5.9% in sNfL (β = 0.589, p < 0.001). Gray band: 95% confidence interval. (B) Association between brain T2 lesion load and sNfL levels in the Lugano cohort (2–9 vs 0–1: β = 1.849, p = 0.001; >9 vs 0–1: β = 2.524, p < 0.001). (C) Association between number of brain gadolinium‐enhancing (GE) lesions and sNfL levels in the Lugano cohort (1 vs 0: β = 1.077, p = 0.630; 2 vs 0: β = 1.551, p = 0.024; ≥3 vs 0: β = 2.138, p = 0.001). (D) Association between brain and spinal cord GE lesions and sNfL levels in the Lugano cohort (either brain or spinal vs neither: β = 1.461, p = 0.005; both brain and spinal vs neither: β = 1.902, p = 0.002).