Table 2.
sNfL Concentration and Associations with Different Clinical and Magnetic Resonance Imaging Variables in the Lugano Cohort
| Variable | Median (IQR)/No. (%) | sNfL, Median (IQR), pg/ml | β | 95% CI | p |
|---|---|---|---|---|---|
| Age, yr | 37.9 (29.8–47.8) | — | 1.015 | 1.006–1.025 | 0.002 |
| Gender | |||||
| F | 92 (64.8%) | 33.0 (21.5–55.3) | — | — | — |
| M | 50 (35.2%) | 44.2 (25.7–62.4) | 1.165 | 0.911–1.489 | 0.226 |
| Oligoclonal bands | |||||
| Negative | 13 (9.1%) | 26.8 (16.8–49.6) | — | — | — |
| Positive | 129 (90.9%) | 36.2 (22.7–61.9) | 1.114 | 0.740–1.676 | 0.606 |
| Brain T2 lesions | |||||
| 0–1 | 16 (11.3%) | 17.3 (11.1–21.8) | — | — | — |
| 2–9 | 61 (43.0%) | 30.2 (21.4–49.6) | 1.849 | 1.283–2.666 | 0.001 |
| >9 | 65 (45.7%) | 48.0 (30.9–69.7) | 2.524 | 1.744–3.653 | <0.001 |
| Brain GE lesions | |||||
| 0 | 89 (63.6%) | 32.7 (21.3–49.7) | — | — | — |
| 1 | 26 (18.6%) | 31.6 (22.6–55.3) | 1.077 | 0.797–1.456 | 0.630 |
| 2 | 15 (10.7%) | 58.3 (28.4–77.0) | 1.551 | 1.064–2.259 | 0.024 |
| ≥3 | 10 (7.1%) | 61.6 (46.4–89.1) | 2.138 | 1.362–3.355 | 0.001 |
| Spinal T2 lesions | |||||
| 0 | 31 (25.0%) | 26.4 (17.2–42.8) | — | — | — |
| 1 | 26 (21.0%) | 25.4 (18.5–42.5) | 0.819 | 0.574–1.167 | 0.271 |
| ≥2 | 67 (54.0%) | 44.0 (29.6–64.6) | 1.332 | 0.992–1.788 | 0.059 |
| Spinal GE lesions | |||||
| 0 | 95 (78.5%) | 32.4 (21.5–53.5) | — | — | — |
| 1 | 26 (21.5%) | 49.2 (30.9–66.0) | 1.467 | 1.091–1.974 | 0.013 |
| Brain/spinal GE lesions | |||||
| Neither | 63 (52.9%) | 29.6 (20.9–41.8) | — | — | — |
| Either | 43 (36.1%) | 43.4 (25.2–65.3) | 1.461 | 1.128–1.892 | 0.005 |
| Both | 13 (10.9%) | 62.5 (42.7–71.4) | 1.902 | 1.278–2.830 | 0.002 |
Age was included as additional variable in all models.
CI = confidence interval; F = female; GE = gadolinium‐enhancing; IQR = interquartile range; M = male; sNfL = serum neurofilament light chain.