Figure 1.

Extreme trait whole-genome sequencing study design. (A) Patient selection and quality control resulted in (B) final analysis using three different group-wise tests comparing rare variants or rare nonsynonymous variants in 65 individuals resistant to emphysema and 64 individuals susceptible to emphysema. F-950 = Hounsfield units value less than −950; MAF = minor allele frequency; Pred = predicted; SCCOR = Specialized Center of Clinically Oriented Research; SNP = single-nucleotide polymorphisms.